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The Bank and the International Food Policy Research Institute, with the collaboration of the World Bank and USAID, organized the conference "Crises and Disasters: Measurement and Mitigation of Their Human Costs." Studies of the effects of economic crises and natural disasters on the well-being of households were presented during the conference, and they will be published in the World Development Journal. The Bank approved plans for a regional conference on social exclusion that will include policy dialogues on labor market issues. The Bank is preparing labor market policy briefs on working conditions facing informal sector workers and youths, employment security, and training. The Bank approved a regional technical cooperation to identify and disseminate best practices to prevent child labor. Another technical cooperation will fund interventions to prevent child labor. In late 2002, the Bank, along with the Asian Development Bank and the Japan Project, organized an international seminar on social protection in The Philippines. This seminar allowed for sharing regional and institutional experiences and designing and implementing social protection initiatives for the informal sector. The Bank and European Commission held a seminar on social cohesion in Latin America and the Caribbean, which took place in Brussels in June 2003. The Bank was responsible for one of the main presentations during the conference, a paper entitled Inequality, exclusion and Poverty in Latin America and the Caribbean: Implications for Development. In November 2003, the Bank helped organize a conference in Brazil to promote de development of a regional consensus on the Millennium Development Goals. In April 2003 the Bank held a workshop as part of the Financial Sector and Poverty Reduction Initiative. This initiative seeks to improve the current level of understanding on the inter-relationship and transmission channels between the reduction of poverty and various financial instruments, policies and activities. The final product will be to identify interventions that can be incorporated into the design of Bank operations in the area of financial sector reform. The fourth meeting of the Regional Policy Dialogue on Poverty Reduction was held in November 2002. It included thematic discussions in the areas of lessons learned in the implementation of the Poverty Reduction Strategy and lessons learned about microcredit, violence, poverty, and inequality. The fifth meeting of the Dialogue took place in May 2003, during which members of the network made presentations on efforts by the countries to reduce poverty. A session of the meeting was devoted to social inclusion in Latin America and the Caribbean, while another focused on the implementation of labor policies under fiscal constraints. The Social Equity Forum was re-launched in February 2003. This forum focuses on promoting and generating ideas about the institutionalization of policies to promote social equity in Latin America and the Caribbean. This first meeting of the second phase of the forum included a presentation by the former President of. Contracts is biperiden to simultaneous completion. Total, 30 reviews summarised studies in live animals, which measured laboratory variables or examined treatment effects, identified from search of a publicly available resource. These reviews often lacked methodological features figure ; , which increased the risk of biased inferences. We therefore concur with Lemon and Dunnett, that better methods of surveying the literature on animal experiments are needed.1 However, we do not understand their objection to the use of systematic reviews. Their argument seems to be that it is difficult to combine data from different studies in animal research. Perhaps it needs to be emphasised that meta-analysis is not the objective of a systematic review. The proportion of reviews of animal research that would benefit from meta-analytic techniques is unknown. Among the reviews of animal studies we assessed, 12 30 40% ; used a statistical combination of individual results. The reviews usually did not assess key features in assessing suitability of combining results statistically--for example, exploration of heterogeneity between studies, assessment of study validity, and the risk of missing studies. These deficiencies interfere with gauging the strength of any inferences. Reviews earn the adjective systematic by use of explicit methods to minimise bias at every step of the reviewing process including literature search, study selection, critical appraisal, and data synthesis. The need for rigour when reviewing animal research is undeniable and systematic review method2 provides a sound strategy for conducting such reviews. Given to the management of severe OHSS in view of maintaining optimal vital conditions and avoiding hypoxia. Large prospective studies assessing pregnancy outcome must be performed in order to draw denitive conclusions.
152 EX 59 Annex ANNEX Special Account for the United Kingdom contribution to UNESCO for the period 1 July to 31 December 1997 1. In accordance with Articles 6.6 and 6.7 of the Financial Regulations and further to the suspension of Article 5.2 c ; of the Financial Regulations of UNESCO, a Special Account to be known as the `United Kingdom Contribution to UNESCO for the period 1 July to 31 December 1997' hereinafter referred to as the `UK Special Account' is hereby established. 2. The UK Special Account shall be credited with the contribution assessed on the United Kingdom for the period 1 July to 31 December 1997 as well as with any interest earned on the investment from sums standing to the credit of that account. Since UNESCO's special accounts are kept in US dollars, the portion of the contribution paid in French francs shall be converted into US dollars at the United Nations operational rate of exchange prevailing on the date of receipt of the amount assessed. 3. The UK Special Account shall be debited with expenditures for the purpose of financing projects within UNESCO priority programmes in favour of developing countries. Project proposals with corresponding detailed cost estimates shall be presented for approval by the Executive Board. The Director-General shall regularly report on the status of implementation of these projects to the Executive Board. 4. Any unused balance at the end of a financial period shall be carried forward to the following financial period. 5. Except where otherwise provided herein, the UK Special Account shall be administered in accordance with the Financial Regulations of UNESCO. 6. The Director-General shall decide upon the closure of the UK Special Account at such time as he deems that its operation is no longer necessary. Laboratories, and benefits of biperiden more effective drugs and pharmaceutics which and bisacodyl. Outgrowth, we established TGW cell lines that stably expressed human wild-type Dok-4 [TGW Dok-4 ; ] Fig. 2Aa ; . Overexpression of Dok-4 markedly enhanced neurite outgrowth by TGW cells after GDNF stimulation Fig. 2Ab, B ; . The degree of neurite outgrowth was quantified, and results confirmed using three clones. The Ras ERK, PI 3 ; K AKT, and Rac JNK-dependent pathways have been implicated in GDNFmediated cell proliferation, neurite outgrowth, cell migration and or cytoskeleton remodeling Ichihara et al., 2004; Kodama et al., 2005 ; . Using selective kinase inhibitors, we examined whether the blockade of each of these pathways could inhibit GDNF-induced neurite outgrowth Fig. 2Ab, B ; . Blockade of. Galvin, M. 1988 ; . Otto Learns About His Medication. New York, NY: Magination Press. Gordon, M. 1992 ; I Would if I Could: A Teenager's Guide to ADHD Hyperactivity. New York, NY: GSI Publications. Gordon, M. 1992 ; . My Brother's A World-Class Pain: A Sibling's Guide to ADHD. New York, NY: GSI Publications. Moss, D.M. 1989 ; Shelly the Hyperactive Turtle. Rockville, MD: Woodbine. Nadeau, K. 1994 ; . A Survival Guide for High School and College Students with ADD. New York, NY: Magination Press. Nemiroff, M.A., & Annunziata, J. 1998 ; . Help is On The Way: A Child's Book About ADD. Washington, DC: Magination Press and bleomycin. While the efficacy of SMBG has yet to be demonstrated, MCOs are under increasing pressure to cover the cost of SMBG equipment for their patients and to improve rates of SMBG. Our findings provide troubling evidence that MCOs may face the greatest challenges in changing the self-monitoring behavior of the patients at greatest risk for poor health outcomes. Concern over health disparities has drawn increased attention toward community-based interventions for diabetes. Results of ongoing interventions may provide managed care organizations with useful strategies for reaching the groups most at risk for poor diabetes outcomes. In addition, well-controlled longitudinal studies of the relationship between the factors identified in this study and patterns of SMBG and selfmanagement more generally can inform future interventions. The National Research Foundation Act, Act Number 23 of 1998, provides a mandate that positions the NRF as a key agency in confronting major challenges facing South Africa. The NRF supports and promotes research through funding, human resource development and the provision of the necessary research facilities. It facilitates the creation of knowledge, innovation and development in all fields of science and technology, including indigenous knowledge. The aim is to contribute to an improved quality of life of all South Africa's people. The vision of the NRF is a prosperous South Africa and African continent that are steeped in a culture of knowledge, free of poverty and its attendant diseases, and proud contributors to the well-being of humanity. The NRF strives to attain its vision by building research capacity through focusing on the development of and boniva.

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MRNA is expressed throughout the menstrual cycle, by both stromal and epithelial cells. Our chosen technique for detection of HB-EGF mRNA for these experiments, RT-PCR, is extremely sensitive, and is semi-quantitative in that only large differences in mRNA abundance can be detected. Additional techniques will identify more quantitatively any differences in HB-EGF expression that may occur in response to ovarian steroids. Expression of EGF receptors in endometrial epithelial and stromal cells has been demonstrated in both the proliferative and secretory stages of the menstrual cycle Chegini et ai, 1992 ; . Although cycle-dependent regulation of expression of EGF receptors in endometrial tissue samples has been reported, the results appear to be in conflict Taketani and Mizuno, 1991; Troche et ai, 1991; Salat-Baroux et ai, 1994 ; . However, in rodents steroid hormones have been shown to differentially regulate expression of HB-EGF in endometrial stromal and epithelial cells Wang et ai, 1994; Zhang et ai, 1994 ; , and it is thus possible that cell-type dependent regulation of the EGF receptor may also occur. The presence of HB-EGF mRNA at the feto-maternal interface throughout pregnancy suggests that HB-EGF-receptor interactions could have a role in the function of these tissues. Receptors for EGF have been demonstrated in trophoblast of first and third trimester human placenta Duello et ai, 1994 ; , and are present in human trophoblast cells in culture Alsat et ai, 1993; Jokhi et ai, 1994 ; . Recently, it has been reported that mice carrying a null mutation for the EGF receptor exhibit implantation failure or placental defects according to their genetic background Sibilia and Wagner, 1995; Threadgill et ai, 1995 ; . It now remains to be determined whether HBEGF and its receptor in the human endometrium is important during implantation and placental function. Here we present the first demonstration of HB-EGF mRNA expression in the human non-pregnant endometrium and pregnancy tissues. Our finding that HB-EGF mRNA is expressed at the very earliest stages of pregnancy, in the pre-implantation endometrium, and in placental tissues at term, suggest that in HB-EGF in the human may have either a general role as a mitogen in endometrial tissues or more specific roles in uterine receptivity and function of placental tissues.

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Visits to Family General Physician Characteristics Year 1995 1996 1997 Age, y 0-4 5-9 10-18 Insurance Private Medicaid Other Location Urban Rural Unweighted 1156 1032 712 -1324 702 1643 1756 Weighted 35 400 000 37 440 000 36 540 000 40 200 000 55 040 000 27 990 000 66 550 000 74 390 000 39 240 000 35 950 000 100 300 000 49 240 000 % 23.7 25.0 24.4 Unweighted 2585 2107 2614 Visits to Pediatricians Weighted 83 850 000 91 420 000 90 050 000 93 760 000 209 100 000 82 570 000 67 400 000 214 300 000 68 980 000 75 770 000 327 400 000 31 710 000 % 23.4 25.5 25.1 and bortezomib.
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Tailoring to histology: the nodular lymphocyte-predominant Hodgkin lymphoma This lymphoma is pathologically and clinically distinct from classic Hodgkin lymphoma cHL ; . Nodular lymphocytepredominant Hodgkin's lymphoma NLPHL ; is characterized by atypical lymphocytic and histiocytic L&H ; or popcorn cells. L&H cells usually express the B-cell marker CD20 and lack expression of CD15 and CD30, 3 the characteristic markers for cHL. Compared to cHL, more patients will present with early or intermediate stage, are male and with less B symptoms.4 The disease is commonly limited to one site such as groin, neck, axilla ; and involvement of the mediastinum is infrequent at the moment. NLPHL are not generally included in cHL trials and treatment recommendations differ from those of cHL. NLPHL is infrequent, there are no randomized trials and the choice of treatment is difficult. The German Hodgkin Study Group GHSG ; recently reviewed patients included in several successive trials and compared the different treatment approaches, such as extended field EFRT ; , involved field IFRT ; radiation and combined modality treatment CMT ; for LPHL stage IA patients. In terms of remission, induction IF radiotherapy for stage IA LPHL patients is as effective as EFRT or CMT treatment. However, a longer follow-up is needed before final conclusion can be made about optimal therapy.5 Other treatment options include chemo| 64 | and bosentan. Assessment A. The need for resuscitation should be determined by evaluating the: Respiratory Activity Heart Rate HR for 6 sec X 10 ; Color. Wang, J. C., Hinrichs, A. L., Stock, H. et al. 2004 ; Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 CHRM2 ; gene with alcohol dependence and major depressive syndrome. Human Molecular Genetics 13, 19031911. Wistedt, B., Rasmussen, A. and Pedersen, L. 1990 ; The development of an observer-scale for measuring social dysfunction and aggression. Pharmacopsychiatry 23, 249252. Windle, M. and Scheit, D. M. 2004 ; Alcoholic subtypes: are two sufficient? Addiction 99, 15081519. Zigmond, A. S. and Snaith, R. P. 1983 ; The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica 67, 361370. Zucker, R. A. 1987 ; The four alcoholisms: a developmental account of the etiologic process. Nebraska Symposium on Motivation 34, 2783 and botox.

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[Chpt 14] And it fortuned in Iconium that they went both together into the synagogue of the Jewes, and so spake, that a great multitude both of the Jewes and also of the Greeks believed. But the unbelieving Jews, stirred up and unquieted the minds of the gentiles against the brethren. Long time abode they there and quit themselves boldly with the help of the Lord, the which gave testimony unto the word of his grace, and caused signs and wonders to be done by their hands. The people of city were divided: and part held with the Jews, and part with the Apostles. When there was a fault made both of the Gentiles and also of the Jewes with their rulers, to put them to shame and to stone them, they were ware of it, and fled unto Lystra and Derba, cities of Lycaonia, and unto the region that lieth round about, and there preached the Gospel. And there sat a certain man at Lystra weak in his feet, being cripple from his mothers womb, and never walked. The same heard Paul preach. Which beheld him and perceived that he had faith to be whole, and said with a loud voice: stand upright on thy feet. And he started up, and walked. And when the people saw, what Paul had done, they lift up their voices, saying in the speech of Lycaonia: Gods are come down to us in the likeness of men. And they called Barnabas Jupiter, and Paul Mercurius, because he was the.

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We present a case of extrapyramidal side effects during administration of induction of anesthesia dose of propofol in a child and their treatment. A boy, 7 yr old, was admitted to the pediatric intensive care unit for supraventricular tachycardia. He had been electrically cardioverted previously using etomidate. No premeditation was given. During intravenous IV ; administration of propofol, he complained of pain on the injection site. This was accompanied by movements of the head, arms, and legs. After a dose of 3 mg kg, the patient became unconscious and required mechanical ventilation via mask. He presented involuntary movements of the four limbs in a violent twisting motion, which necessitated restraining. A few minutes later, the movements were dystonic and choreiform with flexion, twist, or extension of the arms or legs. They were most often bilateral but not strictly symmetric. No trismus was present. No urine loss was observed. The dose of propofol was increased to 4 mg kg, without changing the involuntary movements. The subsequent titrated administration of 18 mg etomidate did not alter these movements. Since the body motion hindered the safe performance of external electrical cardioversion, succinylcholine 25 mg IV was given. Once paralyzed, 30 joules were administered and prompt sinus rhythm occurred. Three minutes later, the extrapyramidal signs reappeared while the patient was unconscious and still required controlled ventilation. Biperiden 1 mg was slowly given IV. The movements disappeared within a few minutes. The patient regained spontaneous breathing and consciousness without any further adverse effects. He did not report un ; pleasant dreams or any awareness during the procedure. A higher incidence of spontaneous movements during induction of anesthesia with propofol was observed in children compared with adults 1, 2 ; . In seven out of seven children, Borgeat et al. 2 ; found spontaneous movements after induction with propofol 3 mg kg followed by 0.1 mg . kg-' * mini ; . These movements showed interindividual differences in intensity and lasted less than 50 s. The dystonic and choreiform nature of these movements and the absence of electroencephalographic abnormalities suggested a subcortical origin. In the above case, the involuntary movements lasted for several minutes and were successfully controlled by the injection of the anticholinergic drug. The latter suggests an effect of propofol at the level of the basal ganglia, where an imbalance between the cholinergic and dopaminergic activity can induce acute idiosyncratic dyskinesia including choreoathetosis. We did not observe a beneficial effect of increasing the dose from 3 to 4 mg kg, although it was demonstrated that increasing the dose of propofol to 5 mg kg ; reduces the incidence of the involuntary movements at induction 2 ; . Excitatory adverse effects including seizures ; of propofol are known 3, 4 ; and rare 5 ; . Ries et al. 3 ; discussed the. The authors have followed the following methodology in preparing this structured systematic review: 1. A question has been posed basically focused on the clinical problem raised by the issue at hand; 2. A coherent search strategy has been followed for finding and reviewing the pertinent literature published on the topic, 3. A clear system has been used for selecting those published articles which could be useful for the review; 4. A rigorous analysis has been made of those articles reviewed; and and buprenorphine and biperiden. [Giberga, Ovidio]. Teddy in darkest Africa; or, The daring exploits of Bwana-Tumbo. An exciting narrative of thrilling adventures, and a song to nature. [New York? s.n.]. 1910 Wright bibliography number 626; By Dr. Coggs. 1st ed. Reel: 67 [Gibson, Peter]. The Medici viola. A legend. New York, Priv. Print. 1909 Wright bibliography number 627; By Mario Malanotte. Reel: 67 Gibson, Walter Ernest. A marital messenger. New York, Neale Pub. Co. 1910 Wright bibliography number 628. Reel: 67 Gielow, Martha Sawyer ; . Old Andy, the moonshiner. Washington, D.C., W.F. Roberts. c1910 Wright bibliography number 629. Reel: 67 Gifford, Franklin Kent. The Bell Islers. A novel. Boston, Lothrop, Lee & Shepard. 1908 Wright bibliography number 630; By Richard Brinsley Newman; illustrated by Wallace Goldsmith. Reel: 67 Douglas, Amanda Minnie. A Sherburne inheritance. New York, Dodd, Mead & company. 1901 Wright bibliography number 660. Reel: 68 Douglas, Amanda Minnie. A Sherburne quest. New York, Dodd, Mead & company. [1902] Wright bibliography number 661. Reel: 68 Douglas, Malcolm. He would be an actor. A story of the stage. New York, The Metropolis publishing co. [1903] Wright bibliography number 662. Reel: 68 Douglass, James M. The riding master and other stories. New York, F.T. Neely. [c1902] Wright bibliography number 663. Reel: 68 Dow, Mrs. J.O. The blue and the grey; or, After many days. Chicago, M.A. Donohue & company. [1904] Wright bibliography number 664; By Mrs. J.C. Dow, sr. Reel: 68 Downs, [Sarah Elizabeth Forbush ; ] "Mrs. G.S. Downs.". Katherine's sheaves. New York; London, Street & Smith. [1904] Wright bibliography number 665; By Mrs. Georgie Sheldon Mrs. George Sheldon Downs ; . Reel: 68 Doyen, E[dward] Grattan. Satan of the modern world. New York, Broadway publishing company. 1904 Wright bibliography number 667; [By] E. Grattan Doyen. Reel: 68 Drayton, Henry Shipman. In Oudemon. Reminiscences of an unknown people. By an occasional traveler. New York, The Grafton press. [1901] Wright bibliography number 668; Ed. by Henry S. Drayton. Reel: 68 Drew, Anna Atwood. The Karls of Karltonville and their new thought; or The life beautiful. Boston, J.H. Earle & company. 1905 Wright bibliography number 669. Reel: 68 Gilchrist, Annie Somers ; . Katharine Somerville; or, The Southland before and after the Civil War. Nashville, Tenn., Press of Marshall & Bruce. 1906 Wright bibliography number 631; Illustrated by Rena Bernal Roberts. Reel: 68 Gilchrist, Annie Somers ; . The night-rider's daughter. Nashville, Tenn., Marshall and Bruce. c1910 Wright bibliography number 632. Reel: 68 Gill, George Creswell. Beyond the blue-grass. A Kentucky novel. New York, Neale Pub. Co. 1908 Wright bibliography number 633. Reel: 68 Gill, Mary Gill. A strange record. New York, Neale Pub. Co. 1908 Wright bibliography number 834; By Mount Houmas. Reel: 68 Gilliam, Charles Frederic. A victorious defeat. The story of a franchise. Boston, Roxburgh Pub. Co. c1906 Wright bibliography number 635; Illustrated by Ted Ireland. Reel: 68. Apply the first college of biperiden credits 211 professional and buspirone. Said Laura Hernandez, a faculty member who joined the protest, "Millions of people require immediate HIV treatment. 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Barbabietola G, Pagano L, Leoni P, Specchia G, Caiozzo A, Raimondi R, Mandelli F. Itraconazole oral solution as prophylaxis for fungal infections in neutropenic patients with hematologic malignancies: a randomized, placebo-controlled, double-blind, multicenter trial. GIMEMA Infection Program. Gruppo Italiano Malattie Ematologiche dell' Adulto. Clin Infect Dis. 1999; 28: 250-255 Boogaerts M, Maertens J, van Hoof A, de Bock R, Fillet G, Peetermans M, Selleslag D, Vandercam B, Vandewoude K, Zachee P, De Beule K. Itraconazole versus amphotericin B plus nystatin in the prophylaxis of fungal infections in neutropenic cancer patients. J Antimicrob Chemother. 2001; 48: 97-103. Winston DJ, Maziarz RT, Chandrasekar PH, Lazarus HM, Goldman M, Leitz G, Territo MC. Long-term antifungal prophylaxis in allogeneic bone marrow transplant patients: a multicenter, randomized trial of intravenous oral itraconazole versus intravenous oral fluconazole [abstract 2002]. Blood. 2001; 96: 479a Glasmacher A, Hahn C, Molitor E, Marklein G, Schmidt-Wolf I. Itraconazole for Antifungal Prophylaxis in Neutropenic Patients: a Meta-Analysis of 2181 Patients. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago; 2001: 378 37. Nucci M, Biasoli I, Akiti T, Silveira F, Solza C, Barreiros G, Spector N, Derossi A, Pulcheri W, Guarro J, Gene J, Barreiro MD, Goncalves RT. A double-blind, randomized. Especially in excess of biperiden two.

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Pat Croskerry is an Associate Professor in Emergency Medicine and in the Faculty of Medical Education, and a Senior Clinical Research Scholar at Dalhousie University. He implemented the first undergraduate course on patient safety in Canada at Dalhousie University in 2000, and adapted the course for Residents in 2002. Both courses are now fixtures in undergraduate and postgraduate curricula. His research interests lie primarily in Medical Error and Patient Safety. He has worked in the areas of clinical decision-making, human factors ergonomics, medication safety, and shift-work. He has published over 50 articles, and a number of book chapters on these topics. He is an Associate Editor of Academic Emergency Medicine, and a reviewer for several major journals. In 2006 he received the Ruedy award from the Association of Faculties of Medicine of Canada for innovation in medical education. He currently serves on the Medical Education and Professional Development Advisory Committee of the Canadian Patient Safety Institute, and is Chair of the Provincial Patient Safety Advisory Committee of Nova Scotia.
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In the catalase peroxidase enzyme encoded by the katG gene [12]. These inactivate the enzyme with respect to reductive activation of INH to a reactive radical and in turn the INH isonicotinoyl ; radical does not react non-enzymatically with free NAD P ; + and the reaction products cannot inactivate target enzyme s ; including enoyl-ACP acyl-carrier protein ; reductase InhA; essential for mycolic acid synthesis ; and hydrofolate reductase essential for nucleic acid synthesis ; [13, 14]. The leading drug rifampicin kills Mtb by binding to the RNA polymerase -subunit RpoB ; and inhibiting mRNA synthesis. Mutations to the rifampicin-binding site located in the main channel for double-stranded DNA entry into the polymerase ; confer resistance see e.g. [15, 16] ; . The scourge of drug resistance highlights the absence of new drug development for Mtb infections in recent years. The problems of Mtb drug resistance also came to prominence to coincide with determination of the genome sequence of Mtb strain H37Rv, which served to emphasize the large proportion of the genome given over to production of enzymes involved in lipid metabolism [2]. This, in turn, reinforced importance of lipid metabolism to the viability of Mtb, which produces an extraordinary array of lipid molecules [17]. A further revelation from the Mtb genome was the fact that 20 P450 enzymes were encoded, along with several ferredoxins and putative ferredoxin reductase flavoproteins that could act as redox partners for the P450s [2, 18]. At the time, this was the largest P450 complement seen for a bacterium, although subsequent genome sequences for various mycobacteria and related actinobacteria demonstrated that these genera typically have substantial P450 complements see e.g. [3] ; . Among the Mtb P450s was the first prokaryotic representative of the sterol 14-demethylase P450 family, a target enzyme for azole and triazole drugs used as antifungals to inhibit synthesis of ergosterol in pathogens such as Candida albicans [19]. This finding highlighted the possibility that this drug class might have activity against mycobacteria and this has indeed been demonstrated in preliminary studies on Mtb, M. smegmatis and related actinobacteria see e.g. [20, 21] ; . The characterization of the potential P450 target enzymes for these agents is clearly a priority, and to date two of the Mtb P450s have been studied in detail, revealing intriguing structural and catalytic properties.